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NSMCE2 Antibody, HRP conjugated

SKU : BHA10513888

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desc-alternative-names-1:(Description) Alternative Names	NSMCE2
desc-antigen-1:(Description) Antigen	E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog), NSMCE2, C8orf36 MMS21
prop-storage-1:(Property) Storage	polyclonal
prop-storage-buffer-1:(Property) Storage Buffer	HRP
targ-uniprot-1	E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
desc-string-3	Liquid
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)
desc-sensitivity-3	Seckel syndrome 10 (SCKL10)
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human
desc-molecular-weight-1	RUO
uniprot-enrty-name	E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	ELISA
desc-chromosome-location-1	ELISA

desc-constituent-1	Q96MF7
desc-function-1	HGNC:26513OMIM:617246KEGG:hsa:286053STRING:9606.ENSP00000287437UniGene:Hs.388297
desc-hgnc-1	E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
desc-gross-weight-kg-1	NSE2 family
desc-guarantee-1	Epigenetics and Nuclear Signaling
desc-immunogen-1	Nucleus, Chromosome, telomere, Nucleus, PML body

desc-involvement-in-disease-1	Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
desc-mgi-1	Liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	>95%, Protein G purified
desc-net-weight-g-1	>95%,Protein G purified
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/11108230/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10513888		100μg	$279.30		Add to Cart
BHA10513888		50μg	$168		Add to Cart

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