Recognizes a protein of 55kDa, identified as CD14 (also known lipopolysaccharide receptor). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.
THP-1 cells and human monocytes. Lymph nodes and tonsils.
elisa-detection
Human
desc-reactivity-1
FALSE
desc-molecular-weight-1
RUO
desc-alternative-names-1
Homo Sapiens (Human)
desc-applications-8
IHC-F
desc-categories-1
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
Immunohistology (Formalin-fixed)1-2μg/ml for 30 minutes at RT
desc-conjugate-1
P08571
desc-description-1:{15}(Description) Description
929
desc-formulation-1:{18}(Description) Formulation
LPSR, 2385
immunogen-region
CD14
desc-intended-use-1
55kDa
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
desc-positive-control-1
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
No Description Available.
No Description Available.
No Description Available.
No Description Available.
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No Description Available.
Reviews of Anti-undefined Antibody LPSR,2385 Unconjugated BHA10208098