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Anti-HIF1 alpha (Hypoxia-Inducible Factor 1-alpha) Antibody BHA10201764

SKU : BHA10201764

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	HIF1 alpha (Hypoxia-Inducible Factor 1-alpha)
desc-antigen-1:(Description) Antigen	ARNT-interacting protein\|Basic-helix-loop-helix-PAS protein MOP1\|Class E basic helix-loop-helix protein 78 (bHLHe78)\|Hypoxia inducible factor 1 alpha\|Member of PAS superfamily 1 (MOP1)\|PAS domain-containing protein 8 (PASD8)
desc-specificity-1:(Description) Specificity	Cytoplasmic, Nuclear
prop-purity-1:(Property) Purity	14q23.2
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant human HIF1 alpha protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG2b Kappa
desc-assay-procedure-3	Cobalt chloride treated HeLa cells. Breast or bladder carcinomas.
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	FACS, IF
desc-categories-1	Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	FACS0.5-1μg/million cells in 0.1mlIF0.5-1μg/ml

desc-conjugate-1	Q16665
desc-constituent-1	597216
desc-description-1:{15}(Description) Description	3091

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201764		100µg	$393.20		Add to Cart

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