desc-alternative-names-1:(Description) Alternative Names
HCC-4 / Liver Expressed Chemokine (LEC)
desc-antigen-1:(Description) Antigen
C-C motif chemokine 16 CCL16|Chemokine CC-4|CKb12|HCC-4|IL-10-inducible chemokine (ILINCK)|LCC-1|Liver-expressed chemokine (Chemokine LEC)|Lymphocyte and monocyte chemoattractant (LMC)|Monotactin-1 (MTN-1)|New CC chemokine 4 (NCC-4)
desc-specificity-1:(Description) Specificity
Extracellular(secreted)
prop-purity-1:(Property) Purity
17q12
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelo-suppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. The ability of HCC-4 to markedly improve recognition of poorly immunogenic cells suggests that it could be an effective component of antitumor vaccines.
Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
ELISAFor coating, order Ab without BSAFuncOrder Ab without BSA & Azide
desc-conjugate-1
O15467
desc-constituent-1
10458
desc-description-1:{15}(Description) Description
3091
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-HCC-4 / Liver Expressed Chemokine (LEC) Antibody BHA10204875