Anti-ER-beta1 (Estrogen Receptor beta-1) Antibody BHA10201024

desc-alternative-names-1:(Description) Alternative Names	ER-beta1 (Estrogen Receptor beta-1)
desc-antigen-1:(Description) Antigen	Erb\|ESR BETA\|ESR2\|ESRB\|ESTRB\|estrogen nuclear receptor beta variant a\|estrogen nuclear receptor beta variant b\|estrogen receptor 2 (ER beta)\|estrogen receptor beta 4
desc-specificity-1:(Description) Specificity	Nuclear
prop-purity-1:(Property) Purity	14q23.2
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	C-terminus fragment of recombinant human estrogen receptor beta protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG2a
desc-assay-procedure-3	MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
elisa-detection	Sheep, Horse, Pig, Mouse, Monkey, Human, Rat
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	IHC-F, WB, IF, FACS
desc-categories-1	(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	FACS0.5-1μg/million cells in 0.1mlIF0.5-1μg/mlWB0.5-1μg/mlIHC-F0.5-1μg/ml for 30 minutes at RT

desc-conjugate-1	Q92731
desc-constituent-1	660607
desc-description-1:{15}(Description) Description	2100

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml