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Home / Antibodies

Anti-Complement 4d (C4d) Antibody BHA10205530

SKU : BHA10205530

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	Complement 4d (C4d)
desc-antigen-1:(Description) Antigen	Acidic Complement C4\|Basic C4\|C4\|C4-1\|C4a Anaphylatoxin\|C4A\|C4A2\|C4A3\|C4A4\|C4A6
desc-specificity-1:(Description) Specificity	Intracytoplasmic vacuoles of endothelial cells(secreted)
prop-purity-1:(Property) Purity	6p21.3
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.ĀC4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant human Complement 4d protein
desc-assay-procedure-3	Rejected Renal Transplant Tissue
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	ELISA, IF
desc-categories-1	Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	ELISAFor coating use Ab at 1-2μg/ml,order Ab without BSAIF0.5-1.0μg/ml

desc-conjugate-1	P0C0L4; P0C0L5
desc-constituent-1	534847; 720022
desc-description-1:{15}(Description) Description	720;721

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205530		100µg	$393.20		Add to Cart

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