desc-alternative-names-1:(Description) Alternative Names
CD32 (Fc Gamma RIIa)
desc-antigen-1:(Description) Antigen
CD32A|Fc fragment of IgG low affinity IIa receptor|Fc gamma RIIa|Fc-gamma RII-a|Fc-gamma-RIIa|FCGR2A|FcgRII|Fcr-2|FcRII-a|IGFR2
desc-specificity-1:(Description) Specificity
Cell Surface
prop-purity-1:(Property) Purity
1q23
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
This MAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (Fc?RII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
Functional Studies (Order Ab without BSA & Azide); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
FACS0.5-1μg/million cells in 0.1mlIF0.5-1μg/ml
desc-conjugate-1
P12318
desc-constituent-1
352642
desc-description-1:{15}(Description) Description
2212
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-CD32 (Fc Gamma RIIa) Antibody BHA10201071