desc-alternative-names-1:(Description) Alternative Names
CD16 / Fcγ Receptor III
desc-antigen-1:(Description) Antigen
FcRIIIa|FCR-10|FcRIII|FCGRIII|FcR-10|Fc fragment of IgG, low affinity IIIa, receptor for (CD16)|neutrophil-specific antigen NA|CD16a|low affinity immunoglobulin gamma Fc region receptor III-A|Fc-gamma RIIIa
desc-specificity-1:(Description) Specificity
Cell Surface
prop-purity-1:(Property) Purity
1q23
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. CD16 is represented by two similar genes, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
FACS0.5-1μg/million cellsIF0.5-1μg/ml
desc-conjugate-1
P08637
desc-constituent-1
372679
desc-description-1:{15}(Description) Description
2214
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-CD16 / Fcγ Receptor III Antibody BHA10201081