Enter to Debug Area Anti-4E-BP1 Antibody (4EB1T37T46-A5) FITC BHA10600004

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Home / Primary Antibodies / Phospho Antibodies

Anti-4E-BP1 Antibody (4EB1T37T46-A5) FITC BHA10600004

SKU : BHA10600004

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Abwiz Bio Inc.

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Mfr.No.	2043
desc-alternative-names-1:(Description) Alternative Names	4E-BP1
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	FITC
targ-uniprot-1	Eukaryotic translation initiation factor 4E-binding protein 1 (PHAS-1, EIF4EBP1, eIF4E-binding protein 1, phospho 4E-BP1) is one member of a family of translation repressor proteins encoded by the EIF4EBP gene (1). The protein directly inhibits cap-dependent translation by binding eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multi-subunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation(2). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of phospho 4E-BP1 to eIF4E, it is thought to prime phospho 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic phospho-peptide corresponding to residues surrounding Thr37/46 of human phospho 4E-BP1.
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
standard-form	Phospho-Thr37, Phospho-Thr46
elisa-detection	Mouse, Human, Rat
desc-sample-type-3	RUO

desc-applications-8	FACS

desc-formulation-1:{18}(Description) Formulation	4EB1T37T46-A5

desc-involvement-in-disease-1	1X PBS, 0.09% NaN3, 0.2% BSA
desc-positive-control-1	2-8ºC

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.abwizbio.com/datasheet/datasheet.php?sku=2043
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600004	2043	100Tests	$320.67		Add to Cart
BHA10600004	2043	10Tests	$120.67		Add to Cart

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