Anti-Btk Antibody (BtkY223-B4) Unconjugated BHA10600031

Mfr.No.	1171
desc-alternative-names-1:(Description) Alternative Names	Btk
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	Unconjugated
targ-uniprot-1	Bruton's tyrosine kinase (Btk) plays a major role in B cell development. B cell activation by various ligands is accompanied by Btk membrane translocation, where ransient phosphorylation at two sites, Tyr551 and Tyr223 create phospho Btk. Tyr551, in the activation loop, is transphosphorylated by the Src family of tyrosine kinases, leading to autophosphorylation at Tyr223. Tyr223 phosphorylation facilitates phospho Btk interaction with activated Syk. Defects in Btk are the cause of X-linked agammaglobulinemia (XLA); also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1).
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human phospho Btk
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
standard-form	phospho-Tyr223
elisa-detection	Mouse, Human
desc-sample-type-3	RUO

desc-applications-8	FACS

desc-formulation-1:{18}(Description) Formulation	BtkY223-B4

desc-involvement-in-disease-1	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
desc-isotype-1:{29}(Description) Isotype	0.5mg/ml
biological-activity	1.0 - 0.1 µg/ml
desc-positive-control-1	-20ºC