Enter to Debug Area Anti-Akt1 Antibody (AktS473-C7) Unconjugated BHA10600014

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Home / Primary Antibodies / Phospho Antibodies

Anti-Akt1 Antibody (AktS473-C7) Unconjugated BHA10600014

SKU : BHA10600014

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Abwiz Bio Inc.

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Mfr.No.	1131
desc-alternative-names-1:(Description) Alternative Names	AKT1
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	Unconjugated
targ-uniprot-1	Akt also known as PKB (Protein kinase B) or RAC-PK (Related to the A and C kinases) is a serine/threonine kinases that contains a pleckstrin homology (PH) domain. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. Phospho-Akt promotes cell survival by inhibiting apoptosis. Specifically, phospho-Akt1 has been shown to phosphorylate Bad, a member of the Bcl-2 family that promotes cell death. This phosphorylation results in the inactivation of the proapoptotic function of Bad. The Akt/phospho Akt molecule is thus considered to link extracellular survival signals (growth factors) with the apoptotic machinery (BAD). Akt is also a key mediator of the metabolic effects of insulin. Additionally, Akt has been referred to as an oncogene because it has increased activity in a number of tumors. This antibody recognizes phospho Akt phosphorylated at Ser473. This phosphorylation site is shared by all three isoforms of phospho Akt. The homologous phosphorylation sites in Akt2 and Akt3 are S474 and S472, respectively.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic phospho-peptide corresponding to residues surrounding Ser473 of human phospho Akt1
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
standard-form	phospho-Ser473
elisa-detection	Mouse, Human
desc-sample-type-3	RUO

desc-applications-8	FACS

desc-formulation-1:{18}(Description) Formulation	AktS473-C7

desc-involvement-in-disease-1	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
desc-isotype-1:{29}(Description) Isotype	0.5mg/ml
biological-activity	1.0 - 0.1 µg/ml
desc-positive-control-1	-20ºC

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.abwizbio.com/datasheet/datasheet.php?sku=1131
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600014	1131	200µl	$466.50		Add to Cart
BHA10600014	1131	20µl	$196.67		Add to Cart

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