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NR1H4 Antibody, FITC conjugated

SKU : BHA10514153

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desc-alternative-names-1:(Description) Alternative Names	NR1H4
desc-antigen-1:(Description) Antigen	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14), NR1H4, BAR FXR HRR1 RIP14
prop-storage-1:(Property) Storage	polyclonal
prop-storage-buffer-1:(Property) Storage Buffer	FITC
targ-uniprot-1	Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
desc-string-3	Liquid
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant Human Bile acid receptor protein (1-476AA)
desc-sensitivity-3	Cholestasis, progressive familial intrahepatic, 5 (PFIC5)
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human
desc-molecular-weight-1	RUO
uniprot-enrty-name	Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	ELISA
desc-chromosome-location-1	ELISA

desc-constituent-1	Q96RI1
desc-function-1	HGNC:7967OMIM:603826KEGG:hsa:9971STRING:9606.ENSP00000447149UniGene:Hs.282735
desc-hgnc-1	Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response
desc-gross-weight-kg-1	Nuclear hormone receptor family, NR1 subfamily
desc-guarantee-1	Signal Transduction
desc-immunogen-1	Nucleus, SUBCELLULAR LOCATION: Isoform 1: Nucleus, SUBCELLULAR LOCATION: Isoform 2: Nucleus, SUBCELLULAR LOCATION: Isoform 3: Nucleus, SUBCELLULAR LOCATION: Isoform 4: Nucleus
desc-immunogen-sequence-1	Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximately equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximately e

desc-involvement-in-disease-1	Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
desc-mgi-1	Liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	>95%, Protein G purified
desc-net-weight-g-1	>95%,Protein G purified
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/1029194/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10514153		100μg	$279.30		Add to Cart
BHA10514153		50μg	$168		Add to Cart

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