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TNFRSF10C Antibody

SKU : BHA10557155

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cusabio

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desc-alternative-names-1:(Description) Alternative Names	TNFRSF10C
desc-antigen-1:(Description) Antigen	LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
targ-uniprot-1	The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.
targ-kegg-3	11906
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant protein of Human TNFRSF10C
desc-isotype-1:{29}(Product Details) Isotype	For research use only. Not for human, diagnostic or therapeutic use.
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human
desc-molecular-weight-1	RUO
uniprot-enrty-name	The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.
desc-description-1:{15}(Product Details) Description	100μl(100μg)
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	ELISA, WB, IHC
desc-cellular-localization-1	WB1:500-1:2000IHC1:50-1:200
desc-chromosome-location-1	ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

cross-reactivity	This protein is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
desc-constituent-1	O14798
desc-function-1	HGNC:11906OMIM:603613KEGG:hsa:8794STRING:9606.ENSP00000349324UniGene:Hs.655801
desc-hgnc-1	Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
desc-host-1	Apoptosis Necroptosis Natural killer cell mediated cytotoxicity
desc-immunogen-1	Cell membrane, Lipid-anchor, GPI-anchor
desc-immunogen-sequence-1	Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

desc-involvement-in-disease-1	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-mgi-1	liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	Affinity purification
desc-net-weight-g-1	Affinity purification
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/1035603/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557155		100μl	$387.33		Add to Cart

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