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SESN1 Antibody

SKU : BHA10556520

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desc-alternative-names-1:(Description) Alternative Names	SESN1
desc-antigen-1:(Description) Antigen	sestrin 1
prop-storage-buffer-1:(Property) Storage Buffer	Non-conjugated
targ-uniprot-1	This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
desc-string-3	Liquid
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Synthetic peptide of human SESN1
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human, Mouse
desc-molecular-weight-1	RUO
uniprot-enrty-name	This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	ELISA, WB
desc-cellular-localization-1	ELISA1:1000-1:2000WB1:200-1:1000
desc-chromosome-location-1	ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000

desc-constituent-1	Q9Y6P5
desc-function-1	HGNC:21595OMIM:606103KEGG:hsa:27244STRING:9606.ENSP00000393762UniGene:Hs.591336
desc-hgnc-1	Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway
desc-host-1	p53 signaling pathway
desc-gross-weight-kg-1	Sestrin family
desc-immunogen-1	Nucleus, Cytoplasm
desc-immunogen-sequence-1	Widely expressed.

desc-involvement-in-disease-1	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
desc-mgi-1	Liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	Antigen affinity purification
desc-net-weight-g-1	Antigen affinity purification
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/11105510/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10556520		100μl	$279.30		Add to Cart
BHA10556520		50μl	$168		Add to Cart

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