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PGR Antibody

SKU : BHA10557323

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desc-alternative-names-1:(Description) Alternative Names	PGR
desc-antigen-1:(Description) Antigen	PGR; NR3C3; PR
targ-uniprot-1	Human progesterone receptor (PR) is expressed as two forms: the full length PR B and the short form PR A. PR A lacks the first 164 amino acid residues of PR . Both PR A and PR B are ligand activated, but differ in their relative ability to activate target gene transcription. The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to full length PR B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms. Phosphorylation of PR B at Ser190 (equivalent to Ser26 of PR A) is catalyzed by CDK2. Mutation of Ser190 results in decreased activity of PR, suggesting that the phosphorylation at Ser190 may be critical to its biological function.
targ-kegg-3	18990
desc-host-1:{21}(Product Details) Host	Mouse
desc-isotype-1:{29}(Product Details) Isotype	For research use only. Not for human, diagnostic or therapeutic use.
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
targ-uniprotkb-3	1924846
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Rat, Mouse, Human
desc-molecular-weight-1	RUO
uniprot-enrty-name	Human progesterone receptor (PR) is expressed as two forms: the full length PR B and the short form PR A. PR A lacks the first 164 amino acid residues of PR . Both PR A and PR B are ligand activated, but differ in their relative ability to activate target gene transcription. The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to full length PR B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms. Phosphorylation of PR B at Ser190 (equivalent to Ser26 of PR A) is catalyzed by CDK2. Mutation of Ser190 results in decreased activity of PR, suggesting that the phosphorylation at Ser190 may be critical to its biological function.
desc-description-1:{15}(Product Details) Description	100μl(100μg)
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	ELISA, WB, IHC
desc-cellular-localization-1	WB1:500-1:2000IHC1:50-1:200
desc-chromosome-location-1	ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

desc-clonality-1:{11}(Description) Clonality	1310285
cross-reactivity	This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
desc-constituent-1	P06401
desc-function-1	HGNC:8910OMIM:607311KEGG:hsa:5241STRING:9606.ENSP00000325120UniGene:Hs.32405
desc-hgnc-1	The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
desc-host-1	Estrogen signaling pathway
desc-gross-weight-kg-1	Nuclear hormone receptor family, NR3 subfamily
desc-guarantee-1	Transcription
desc-immunogen-1	Nucleus, Cytoplasm, Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent, On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases, SUBCELLULAR LOCATION: Isoform A: Nucleus, Cytoplasm
desc-immunogen-sequence-1	In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of th

desc-involvement-in-disease-1	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-mgi-1	liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	Affinity purification
desc-net-weight-g-1	Affinity purification
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/158163/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557323		100μl	$387.33		Add to Cart

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