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HNF4A Antibody

SKU : BHA10557314

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desc-alternative-names-1:(Description) Alternative Names	HNF4A
desc-antigen-1:(Description) Antigen	HNF4A; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
targ-uniprot-1	Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY).
targ-kegg-3	5024
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic peptide of Human HNF4A
desc-isotype-1:{29}(Product Details) Isotype	For research use only. Not for human, diagnostic or therapeutic use.
desc-sensitivity-3	Maturity-onset diabetes of the young 1 (MODY1); Diabetes mellitus, non-insulin-dependent (NIDDM); Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4)
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
targ-uniprotkb-3	109128
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human, Mouse, Rat
desc-molecular-weight-1	RUO
uniprot-enrty-name	Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY).
desc-description-1:{15}(Product Details) Description	100μl(100μg)
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	IHC, ELISA, WB
desc-cellular-localization-1	WB1:500-1:2000IHC1:50-1:200
desc-chromosome-location-1	ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

desc-clonality-1:{11}(Description) Clonality	2810
cross-reactivity	This protein is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.
desc-constituent-1	P41235
desc-function-1	HGNC:5024OMIM:125850KEGG:hsa:3172STRING:9606.ENSP00000312987UniGene:Hs.116462
desc-hgnc-1	Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
desc-host-1	AMPK signaling
desc-gross-weight-kg-1	Nuclear hormone receptor family, NR2 subfamily
desc-immunogen-1	Nucleus

desc-involvement-in-disease-1	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-mgi-1	liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	Affinity purification
desc-net-weight-g-1	Affinity purification
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/1035677/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557314		100μl	$387.33		Add to Cart

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