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FEN1 Antibody

BHA10557168
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desc-applications-8 IHC, ELISA, WB
desc-cellular-localization-1 WB1:500-1:2000IHC1:50-1:200
desc-chromosome-location-1 ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
desc-clonality-1:{11}(Description) Clonality 620583
cross-reactivity This protein removes 5 overhanging flaps in DNA repair and processes the 5 ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 end of the flap that is necessary for both binding and cleavage by This protein. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
desc-constituent-1 P39748
desc-function-1 HGNC:3650OMIM:600393KEGG:hsa:2237STRING:9606.ENSP00000305480UniGene:Hs.409065
desc-hgnc-1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
desc-host-1 DNA repair pathway
desc-gross-weight-kg-1 XPG/RAD2 endonuclease family, FEN1 subfamily
desc-immunogen-1 Isoform 1: Nucleus, nucleolus, Nucleus, nucleoplasm
desc-involvement-in-disease-1 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-mgi-1 liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight Affinity purification
desc-net-weight-g-1 Affinity purification
desc-positive-control-1 Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1 Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-recombinant-1 Datasheet
desc-recommended-dilution-1 https://www.cusabio.com/datasheet/158007/
desc-regulatory-1 (pdf)
SKU Supplier No. Size Your price Quantity
BHA10557168 100μl $387.33
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