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ERCC5 Antibody

SKU : BHA10557235

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cusabio

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desc-alternative-names-1:(Description) Alternative Names	ERCC5
desc-antigen-1:(Description) Antigen	ERCC5; XPG; UVDR; XPGC; COFS3; ERCM2
targ-uniprot-1	This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
targ-kegg-3	3437
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant protein of Human ERCC5
desc-isotype-1:{29}(Product Details) Isotype	For research use only. Not for human, diagnostic or therapeutic use.
desc-sensitivity-3	Xeroderma pigmentosum complementation group G (XP-G); Cerebro-oculo-facio-skeletal syndrome 3 (COFS3)
appl-tested-application-1:{73}(Product Details) Tested Application	IgG
targ-uniprotkb-3	103582
prop-storage-1:{106}(Product Details) Storage	Rabbit
elisa-detection	Human, Mouse, Rat
desc-molecular-weight-1	RUO
uniprot-enrty-name	This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
desc-description-1:{15}(Product Details) Description	100μl(100μg)
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	IHC, ELISA, WB
desc-cellular-localization-1	WB1:500-1:2000IHC1:50-1:200
desc-chromosome-location-1	ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

desc-clonality-1:{11}(Description) Clonality	1586176
cross-reactivity	Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined.
desc-constituent-1	P28715
desc-function-1	HGNC:3437OMIM:133530KEGG:hsa:2073STRING:9606.ENSP00000347978UniGene:Hs.258429
desc-hgnc-1	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
desc-host-1	DNA repair pathway
desc-gross-weight-kg-1	XPG/RAD2 endonuclease family, XPG subfamily
desc-immunogen-1	Nucleus

desc-involvement-in-disease-1	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
desc-mgi-1	liquid
desc-molecular-weight-1:{32}(Description) Molecular Weight	Affinity purification
desc-net-weight-g-1	Affinity purification
desc-positive-control-1	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
desc-precautions-1	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.cusabio.com/datasheet/1035639/
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557235		100μl	$387.33		Add to Cart

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