Enter to Debug Area Anti-Zap70/Syk Antibody (Zap70Y493-H11) FITC BHA10600159

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Home / Primary Antibodies / Phospho Antibodies

Anti-Zap70/Syk Antibody (Zap70Y493-H11) FITC BHA10600159

SKU : BHA10600159

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Abwiz Bio Inc.

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Mfr.No.	1163
desc-alternative-names-1:(Description) Alternative Names	Zap70/Syk
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	FITC
targ-uniprot-1	ZAP70 (Tyrosine-protein kinase ZAP-70, phospho Zap70) is a protein tyrosine kinase (PTK) that associates with the z subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus. It appears that both phospho Zap70 and Syk are recruited to the phosphorylated CD3 and z subunits after TCR stimulation. Phosphorylation of Tyr319 is required for the assembly of a phospho Zap70-containing signaling complex that leads to the activation of the PLC-gamma1-dependent and Ras-dependent signaling cascades in antigen-stimulated T cells. The orthologous Tyr352 residue in Syk is also involved in the association with PLC-gamma1. Phosphorylation of Tyr493 within the activation loop results in enzymatic activation of phospho Zap70.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic phospho-peptide corresponding to residues surrounding Tyr493 of human phospho Zap70
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
standard-form	phospho-Tyr493/Tyr526
elisa-detection	Human, Mouse
desc-sample-type-3	RUO

desc-applications-8	FACS

desc-formulation-1:{18}(Description) Formulation	Zap70Y493-H11

desc-involvement-in-disease-1	1X PBS, 0.09% NaN3, 0.2% BSA
desc-positive-control-1	2-8ºC

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.abwizbio.com/datasheet/datasheet.php?sku=1163
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600159	1163	100Tests	$320.67		Add to Cart
BHA10600159	1163	10Tests	$120.67		Add to Cart

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