Anti-undefined Antibody C40,1605 Unconjugated BHA10208124

desc-alternative-names-1:(Description) Alternative Names	CD40 / TNFRSF5 / CD40L-Receptor
desc-antigen-1:(Description) Antigen	B-cell surface antigen CD40\|Bp50\|CD40\|CD40L receptor\|GP39\|HIGM1\|IGM\|IMD3\|p50\|TBAM\|TNF receptor superfamily member 5\|TNFRSF5\|TRAP
desc-specificity-1:(Description) Specificity	Secreted, Cell Surface
prop-purity-1:(Property) Purity	20q12-q13.2
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	Unconjugated
targ-uniprot-1	CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant full-length human CD40 protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
desc-assay-procedure-3	L-428 Cells. Tonsil, Spleen or Thymus
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	IHC-F
desc-categories-1	Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	Immunohistology (Formalin-fixed)1-2μg/ml for 30 minutes at RT

desc-conjugate-1	P25942
desc-description-1:{15}(Description) Description	958
desc-formulation-1:{18}(Description) Formulation	C40, 1605
immunogen-region	CD40
desc-intended-use-1	43kDa

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
desc-positive-control-1	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.