Enter to Debug Area Anti-CPS1 / Carbamoyl-Phosphate Synthetase Antibody BHA10200583

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Anti-CPS1 / Carbamoyl-Phosphate Synthetase Antibody BHA10200583

SKU : BHA10200583

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	CPS1 / Carbamoyl-Phosphate Synthetase
desc-antigen-1:(Description) Antigen	Carbamoyl-phosphate synthetase 1 (CPS1)\|Carbamoylphosphate synthetase 1\|CPSase 1\|CPSASE1
desc-specificity-1:(Description) Specificity	Finely granular cytoplasmic
prop-purity-1:(Property) Purity	2q35
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.ĀDeficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant human CPS1 protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1
desc-assay-procedure-3	HeLa cells. Liver or Hepatocellular Carcinoma (HCC)
elisa-detection	Human, Dog
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	IF, IHC-F, IHC(ap)
desc-categories-1	(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	IF0.5-1.0μg/mlIHC-F0.25-0.5μg/ml for 30 minutes at RTIHC(ap)

desc-conjugate-1	P31327
desc-constituent-1	149252
desc-description-1:{15}(Description) Description	1373

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200583		100µg	$393.20		Add to Cart

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