Enter to Debug Area Anti-Chk1 Antibody (Chk1S317-F10) APC BHA10600034

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Home / Primary Antibodies / Phospho Antibodies

Anti-Chk1 Antibody (Chk1S317-F10) APC BHA10600034

SKU : BHA10600034

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Abwiz Bio Inc.

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Mfr.No.	2154
desc-alternative-names-1:(Description) Alternative Names	Chk1
prop-storage-1:(Property) Storage	monoclonal
prop-storage-buffer-1:(Property) Storage Buffer	APC
targ-uniprot-1	The act of DNA damaged response and cell cycle checkpoints requires the activation of four protein kinases that form the canonical ATR-Chk1 and ATM-Chk2 pathways. ATR activation requires the generation of structures containing single strand DNA (ssDNA) adjacent to double strand DNA (dsDNA). Such ssDNA is coated with replication protein A complex and attracts ATR (1,2). The accumulation of ATR to damage sites results in initial activation of ATR. ATR phosphorylates proteins at the ssDNA which are called checkpoint regulators. The accumulation and phosphorylation of these checkpoint regulators further stimulates the catalytic activity of ATR. ATR-induced Chk1 phosphorylation likely occurs at the sites of DNA damage on chromatin (3-5). The activated ATR phosphorylates Chk1 at Ser317 and Ser345 in its C-terminal regulatory domain. Phospho Chk1 is critical for DNA damage checkpoint activation, replication control, and cell viability (6-8). Functionally, ATR-mediated phosphorylation elevates phospho Chk1 catalytic activity. The N-terminal catalytic domain of Chk1 adopts an open kinase conformation and the deletion of C-terminal domain increases Chk1 catalytic activity.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
standard-form	phospho-Ser317
elisa-detection	Human, Mouse
desc-sample-type-3	RUO

desc-applications-8	FACS

desc-formulation-1:{18}(Description) Formulation	Chk1S317-F10

desc-involvement-in-disease-1	1X PBS, 0.09% NaN3, 0.2% BSA
desc-positive-control-1	2-8ºC

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.abwizbio.com/datasheet/datasheet.php?sku=2154
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600034	2154	100Tests	$320.67		Add to Cart
BHA10600034	2154	10Tests	$120.67		Add to Cart

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