desc-alternative-names-1:(Description) Alternative Names
Blood Group Antigen A (CD173)
desc-antigen-1:(Description) Antigen
A transferase|ABO|B transferase|CD173|Fucosylglycoprotein 3-alpha-galactosyltransferase|Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase|Glycoprotein-fucosylgalactoside alpha-galactosyltransferase|Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase|Histo-blood group A transferase|Histo-blood group B transferase
desc-specificity-1:(Description) Specificity
Cell Surface
prop-purity-1:(Property) Purity
9q34.2
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
This MAb preferably reacts with determinants of chain A and H type 3Ā(Gal1-3GalNAc-R) and 4 (Gal1-3GalNAc-R), but not with type 1 and 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This MAb is applicable for tissue staining in tumor patients with blood groups A and AB. It shows a highly heterogeneous reactivity in human colon tumor tissue and adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
IF0.5-1μg/mlIHC-F0.5-1.0μg/ml for 30 minutes at RT
desc-conjugate-1
P16442
desc-constituent-1
654423
desc-description-1:{15}(Description) Description
28
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-Blood Group Antigen A (CD173) Antibody BHA10201598