Enter to Debug Area Anti-PRKAA2/PRKAA1 Antibody BHA11302571

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Anti-PRKAA2/PRKAA1 Antibody BHA11302571

SKU : BHA11302571

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desc-alternative-names-1:(Description) Alternative Names	PRKAA2/PRKAA1
desc-antigen-1:(Description) Antigen	5'-AMP-activated protein kinase catalytic subunit alpha-1\|AMPK subunit alpha-1\|Acetyl-CoA carboxylase kinase\|ACACA kinase\|Hydroxymethylglutaryl-CoA reductase kinase\|HMGCR kinase\|au-protein kinase PRKAA1\|PRKAA1\|AMPK1\|5'-AMP-activated protein kinase catalytic subunit alpha-2\|AMPK subunit alpha-2\|Acetyl-CoA carboxylase kinase\|ACACA kinase\|Hydroxymethylglutaryl-CoA reductase kinase\|HMGCR kinase\|PRKAA2\|AMPK\|AMPK2
prop-storage-1:(Property) Storage	polyclonal
targ-uniprot-1	AMPK is a heterotrimeric complex comprising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKα1 and AMPKα2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKβ1 encodes a 271 amino acid protein and human AMPKβ2 encodes a 272 amino acid protein. The human AMPKγ1 gene encodes a 331 amino acid protein. Human AMPKγ2 and AMPKγ3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Synthetic phosphopeptide derived from human AMPKα1 around the phosphorylation site of Threonine 183.
standard-form	phospho-T183/172
elisa-detection	Human, Mouse, Rat
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	WB, IHC
desc-cellular-localization-1	WB1:500-1:1000IHC1:50-1:200

desc-conjugate-1	Q13131/P54646
desc-constituent-1	Q13131/P54646
desc-intended-use-1	63 kDa

instructions-for-use	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: p-AMPKα1/2 (T183/172) polyclonal antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at Thr183 and AMPKα2 protein only when phosphorylated at Thr172.
desc-net-weight-g-1	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
desc-positive-control-1	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.bioworlde.com/pdf/BS4457.pdf
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302571		50µl	$199.33		Add to Cart
BHA11302571		100µl	$314.89		Add to Cart

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