Enter to Debug Area Anti-LAT Antibody BHA11302648

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Anti-LAT Antibody BHA11302648

SKU : BHA11302648

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desc-alternative-names-1:(Description) Alternative Names	LAT
desc-antigen-1:(Description) Antigen	Linker for activation of T-cells family member 1\|36 kDa phospho-tyrosine adapter protein\|pp36\|p36-38\|LAT
prop-purity-1:(Property) Purity	16q13
prop-storage-1:(Property) Storage	polyclonal
targ-uniprot-1	LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Synthetic phosphopeptide derived from human LAT (Isoform Short) around the phosphorylation site of Tyrosine 191.
standard-form	phospho-Y191
elisa-detection	Human, Mouse, Rat
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	WB, IHC
desc-cellular-localization-1	WB1:500-1:1000IHC1:50-1:200

desc-conjugate-1	O43561
desc-constituent-1	O43561
desc-intended-use-1	38 kDa

instructions-for-use	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: p-LAT (Y191) polyclonal antibody detects endogenous levels of human LAT (Isoform Short) only when phosphorylated at Tyr191, and detects LAT (Isoform Long) only when phosphorylated at Tyr220.
desc-net-weight-g-1	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
desc-positive-control-1	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.bioworlde.com/pdf/BS4702.pdf
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302648		50µl	$199.33		Add to Cart
BHA11302648		100µl	$314.89		Add to Cart

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