Enter to Debug Area Anti-IRS1 Antibody BHA11302393

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Anti-IRS1 Antibody BHA11302393

SKU : BHA11302393

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desc-alternative-names-1:(Description) Alternative Names	IRS1
desc-antigen-1:(Description) Antigen	Insulin receptor substrate 1\|IRS-1\|IRS1
prop-purity-1:(Property) Purity	2q36.3
prop-storage-1:(Property) Storage	polyclonal
targ-uniprot-1	IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 307.
standard-form	phospho-S307
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO
desc-alternative-names-1	Homo Sapiens (Human)

desc-applications-8	WB, IHC
desc-cellular-localization-1	WB1:500-1:1000IHC1:50-1:200

desc-conjugate-1	P35568
desc-constituent-1	P35568
desc-intended-use-1	; 132, 180 kDa

instructions-for-use	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: P-IRS-1 (S307) polyclonal antibody detects endogenous levels of IRS-1 protein only when phosphorylated at Ser307
desc-net-weight-g-1	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
desc-positive-control-1	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.bioworlde.com/pdf/BS4104.pdf
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302393		50µl	$199.33		Add to Cart
BHA11302393		100µl	$314.89		Add to Cart

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