Enter to Debug Area Anti-IKBKB/CHUK Antibody BHA11302805

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Anti-IKBKB/CHUK Antibody BHA11302805

SKU : BHA11302805

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desc-alternative-names-1:(Description) Alternative Names	IKBKB/CHUK
desc-antigen-1:(Description) Antigen	I kappa-B kinase alpha\|IkBKA\|IKK-alpha\|IKK-A\|IkappaB kinase\|EC 2.7.11.10\|I-kappa-B kinase 1\|IKK1\|Conserved helix-loop-helix ubiquitous kinase\|Nuclear factor NF-kappa-B inhibitor kinase alpha\|NFKBIKA\|CHUK\|IKKA\|TCF16
prop-storage-1:(Property) Storage	polyclonal
targ-uniprot-1	The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins. Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
desc-host-1:{21}(Product Details) Host	Mouse
standard-form	phospho-S180/181
elisa-detection	Human, Mouse, Rat
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	IHC
desc-cellular-localization-1	IHC1:50-1:200

desc-conjugate-1	O15111/O14920
desc-constituent-1	O15111/O14920
desc-intended-use-1	85 kDa

instructions-for-use	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: p-IKKa/b (S180/181) polyclonal antibody detects endogenous levels of IKKa/b protein when phosphorylated at Ser180/181.
desc-net-weight-g-1	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
desc-positive-control-1	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

desc-recombinant-1	Datasheet
desc-recommended-dilution-1	https://www.bioworlde.com/pdf/BS5082.pdf
desc-regulatory-1	(pdf)

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302805		50µl	$199.33		Add to Cart
BHA11302805		100µl	$314.89		Add to Cart

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