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Home / Antibodies

Anti-IgA (Immunoglobulin Alpha Heavy Chain) Antibody BHA10202109

SKU : BHA10202109

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	IgA (Immunoglobulin Alpha Heavy Chain)
desc-antigen-1:(Description) Antigen	A2m Marker\|Ig alpha 1 Chain C Region\|Ig alpha 2 Chain C Region\|IGHA1\|IGHA2\|Immunoglobulin Am1\|Immunoglobulin Am2\|Immunoglobulin Heavy Constant Alpha 1\|Immunoglobulin Heavy Constant Alpha 2
desc-specificity-1:(Description) Specificity	Cell Surface, Cytoplasmic (Secreted)
prop-purity-1:(Property) Purity	14q32.33
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.ĀIgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Purified human IgA
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
desc-assay-procedure-3	Daudi, 293T, Raji or hPBL cells. Tonsil or Spleen.
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	FACS, IF, IHC-F
desc-categories-1	(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	FACS1-2μg/million cells in 0.1mlIF0.5-1.0μg/ml 30 min RTIHC-F0.5-1.0μg/ml 30 min RT

desc-conjugate-1	P01876; P01877
desc-constituent-1	699841
desc-description-1:{15}(Description) Description	3493;3494

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202109		100µg	$393.20		Add to Cart

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