desc-alternative-names-1:(Description) Alternative Names
HLA-DRB (MHC II)
desc-antigen-1:(Description) Antigen
DRB1|HLA class II histocompatibility antigen, DR-1 beta chain|HLA-DR-beta 1|HLA-DRB1|human leucocyte antigen DRB1|Leucocyte antigen DR beta 1 chain|lymphocyte antigen DRB1|major histocompatibility complex, class II, DR beta 1|MHC class II HLA-DR beta 1 chain|MHC class II HLA-DR-beta cell surface glycoprotein
desc-specificity-1:(Description) Specificity
Cell Surface
prop-purity-1:(Property) Purity
6p21.3
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
FACS0.5-1μg/million cellsIF0.5-1μg/mlWB0.5-1μg/mlIHC-F0.25-0.5μg/ml for 30 minutes at RT
desc-conjugate-1
P01911 (Human)
desc-constituent-1
534322 (Human)
desc-description-1:{15}(Description) Description
3123 (Human)
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-HLA-DRB (MHC II) Antibody BHA10201864