desc-alternative-names-1:(Description) Alternative Names
HLA-DRA (MHC II)
desc-antigen-1:(Description) Antigen
DR alpha chain|HLA class II histocompatibility antigen|HLA class II histocompatibility antigen DR alpha chain|HLA DRA|HLA DRA1|HLA-DRA|HLADRA1|Major histocompatibility complex class II DR alpha|MHC cell surface glycoprotein|MHC class II antigen DRA
desc-specificity-1:(Description) Specificity
Cell Surface
prop-purity-1:(Property) Purity
6p21.3
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
FACS0.5-1μg/million cells in 0.1mlIF0.5-1μg/ml
desc-conjugate-1
P01903
desc-constituent-1
520048
desc-description-1:{15}(Description) Description
3122
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Reviews of Anti-HLA-DRA (MHC II) Antibody BHA10201853