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Home / Antibodies

Anti-Fascin-1 Antibody BHA10204987

SKU : BHA10204987

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	Fascin-1
desc-antigen-1:(Description) Antigen	55kDa actin-bundling protein\|FAN1\|Fascin homolog 1\|Fascin1\|FSCN1\|HSN\|p55\|Singed (Drosophila) like (sea urchin fascin homolog like)\|SNL
desc-specificity-1:(Description) Specificity	Cytoplasmic
prop-purity-1:(Property) Purity	7p22.1
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkinā€™s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Full length recombinant human FSCN1 protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG2a Kappa
desc-assay-procedure-3	HeLa, MCF-7, PC-3 or BEWO cells. Hodgkin’s lymphoma, Ovarian or Testicular Carcinoma.
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	FACS, IHC-F, WB, IF
desc-categories-1	(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	FACS0.5-1μg/million cells in 0.1mlIF1-2μg/mlWB0.5-1.0μg/mlIHC-F0.5-1μg/ml for 30 minutes at RT

desc-conjugate-1	Q16658
desc-constituent-1	118400
desc-description-1:{15}(Description) Description	6624

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204987		100µg	$393.20		Add to Cart

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