desc-alternative-names-1:(Description) Alternative Names
CDX2
desc-antigen-1:(Description) Antigen
Caudal type homeobox 2|Caudal type homeobox transcription factor 2|Caudal-type homeobox protein 2|CDX2
desc-specificity-1:(Description) Specificity
Nuclear
prop-purity-1:(Property) Purity
13q12.2
prop-storage-1:(Property) Storage
monoclonal
targ-uniprot-1
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
desc-cellular-localization-1
ELISAUse Ab at 2-4μg/ml for coatingFACS0.5-1μg/million cellsIF1-2μg/mlIHC-F0.5-1μg/ml for 30 min at RT
desc-conjugate-1
Q99626
desc-constituent-1
174249
desc-description-1:{15}(Description) Description
1045
desc-involvement-in-disease-1
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype
1.0mg/ml
instructions-for-use
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.