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Home / Antibodies

Anti-CD95 / FAS / TNFRSF6 Antibody BHA10202370

SKU : BHA10202370

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NeoBiotechnologies, Inc.

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desc-alternative-names-1:(Description) Alternative Names	CD95 / FAS / TNFRSF6
desc-antigen-1:(Description) Antigen	ALPS1A\|Apoptosis APO1 antigen 1\|Apoptosis-mediating surface antigen FAS\|APT1\|Delta Fas/APO1/CD95\|Fas (TNF receptor superfamily\|member 6)\|Fas AMA\|Fas cell surface death receptor\|FAS1
desc-specificity-1:(Description) Specificity	Cell Surface
prop-purity-1:(Property) Purity	10q24.1
prop-storage-1:(Property) Storage	monoclonal
targ-uniprot-1	MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
desc-host-1:{21}(Product Details) Host	Mouse
prop-purification-1:{101}(Product Details) Purification	Recombinant human CD95 protein
appl-tested-application-1:{73}(Product Details) Tested Application	IgG1 Kappa
desc-assay-procedure-3	MCF-7 cells; hepatocellular or bladder carcinoma
elisa-detection	Human
desc-reactivity-1	FALSE
desc-molecular-weight-1	RUO

desc-applications-8	FACS, IF, IHC-F
desc-categories-1	Functional Studies (Order Ab without Azide); Optimal dilution for a specific application should be determined.
desc-cellular-localization-1	FACS0.5-1μg/million cells in 0.1mlIF0.5-1μg/mlIHC-F0.5-1μg/ml for 30 minutes at RT

desc-conjugate-1	P25445
desc-constituent-1	244139
desc-description-1:{15}(Description) Description	355

desc-involvement-in-disease-1	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
desc-isotype-1:{29}(Description) Isotype	1.0mg/ml
instructions-for-use	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
desc-net-weight-g-1	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202370		100µg	$393.20		Add to Cart

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